Use of corticosteroids in treating non-infectious uveitis: an update
- Department of Ophthalmology, Faculty of Medicine, University of Health Sciences, Vietnam National University –Ho Chi Minh City, Ho Chi Minh City, Vietnam
- Department of Ophthalmology, Gia Dinh People’s Hospital, Ho Chi Minh City, Vietnam
Abstract
Uveitis is characterized by the inflammation of the uveal tract, the vascular membrane of the ocular globe. Its etiologies are divided into two main categories: infectious and non-infectious. Corticos-teroids are an important class of medications that have been used in the treatment of uveitis for decades. They can be administered either systemically (orally or intravenously) or locally (topical drops, periorbital injection, intravitreal injection, suprachoroidal injection, or intravitreal implant).
This review updates and describes each of the currently available corticosteroid options for treating uveitis, along with their respective advantages and disadvantages. The main advantage of corticos-teroids in treating uveitis is their ability to quickly and effectively control the inflammatory response.
However, their use may result in various side effects, either local (cataract, elevated intraocular pres-sure) or systemic (osteonecrosis, adrenal insufficiency, Cushing syndrome). Overall, corticosteroids are not an appropriate option for long-term treatment of uveitis.